Determination of isosorbide-5-mononitrate in tablets by differential pulse polarography.
Pharm Acta Helv
; 64(4): 125-8, 1989.
Article
en En
| MEDLINE
| ID: mdl-2726993
ABSTRACT
A differential pulse polarographic method requiring little sample separation was developed for the determination of isosorbide-5-mononitrate in tablet dosage form with the standard addition technique and without interference from common excipients. Britton-Welford buffer (pH 3.0) was used as the supporting electrolyte, the single peak occurring at -0.36 V vs. a reference Ag/AgCl electrode. The irreversible, diffusion controlled, two-electron reduction process at the dropping mercury electrode permits a precise and accurate determination of the active ingredient in the 0.4-20 microgram/ml concentration range.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dinitrato de Isosorbide
Idioma:
En
Revista:
Pharm Acta Helv
Año:
1989
Tipo del documento:
Article