Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.

Fox, Raymond G; Lytle, Nikki K; Jaquish, Dawn V; Park, Frederick D; Ito, Takahiro; Bajaj, Jeevisha; Koechlein, Claire S; Zimdahl, Bryan; Yano, Masato; Kopp, Janel; Kritzik, Marcie; Sicklick, Jason; Sander, Maike; Grandgenett, Paul M; Hollingsworth, Michael A; Shibata, Shinsuke; Pizzo, Donald; Valasek, Mark; Sasik, Roman; Scadeng, Miriam; Okano, Hideyuki; Kim, Youngsoo; MacLeod, A Robert; Lowy, Andrew M; Reya, Tannishtha

Fox, Raymond G; Lytle, Nikki K; Jaquish, Dawn V; Park, Frederick D; Ito, Takahiro; Bajaj, Jeevisha; Koechlein, Claire S; Zimdahl, Bryan; Yano, Masato; Kopp, Janel; Kritzik, Marcie; Sicklick, Jason; Sander, Maike; Grandgenett, Paul M; Hollingsworth, Michael A; Shibata, Shinsuke; Pizzo, Donald; Valasek, Mark; Sasik, Roman; Scadeng, Miriam; Okano, Hideyuki; Kim, Youngsoo; MacLeod, A Robert; Lowy, Andrew M; Reya, Tannishtha.

Afiliación

Fox RG; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine La Jolla, CA.
Lytle NK; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
Jaquish DV; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA.
Park FD; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine La Jolla, CA.
Ito T; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
Bajaj J; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA.
Koechlein CS; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA.
Zimdahl B; Department of Surgery, Division of Surgical Oncology, University of California San Diego School of Medicine, La Jolla, CA.
Yano M; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine La Jolla, CA.
Kopp J; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
Kritzik M; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA.
Sicklick J; Department of Medicine, Division of Gastroenterology, University of California San Diego School of Medicine, La Jolla, CA.
Sander M; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine La Jolla, CA.
Grandgenett PM; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
Hollingsworth MA; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA.
Shibata S; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine La Jolla, CA.
Pizzo D; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
Valasek M; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA.
Sasik R; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine La Jolla, CA.
Scadeng M; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
Okano H; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA.
Kim Y; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine La Jolla, CA.
MacLeod AR; Sanford Consortium for Regenerative Medicine, La Jolla, CA.
Lowy AM; Moores Cancer Center, University of California San Diego School of Medicine, La Jolla, CA.
Reya T; Department of Physiology, Graduate School of Medicine, Keio University, Keio, Japan.

Nature ; 534(7607): 407-411, 2016 06 16.

Article en En | MEDLINE | ID: mdl-27281208

Asunto(s)

Carcinoma Ductal Pancreático/tratamiento farmacológico; Resistencia a Antineoplásicos/efectos de los fármacos; Imagen Molecular; Proteínas del Tejido Nervioso/genética; Neoplasias Pancreáticas/tratamiento farmacológico; Proteínas de Unión al ARN/genética; Animales; Carcinoma in Situ/genética; Carcinoma in Situ/patología; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/metabolismo; Carcinoma Ductal Pancreático/patología; Transformación Celular Neoplásica/genética; Modelos Animales de Enfermedad; Progresión de la Enfermedad; Resistencia a Antineoplásicos/genética; Femenino; Eliminación de Gen; Genes Reporteros/genética; Humanos; Masculino; Ratones; Modelos Genéticos; Células Neoplásicas Circulantes/metabolismo; Proteínas del Tejido Nervioso/deficiencia; Proteínas del Tejido Nervioso/metabolismo; Oligonucleótidos Antisentido/administración & dosificación; Oligonucleótidos Antisentido/genética; Oligonucleótidos Antisentido/farmacocinética; Oligonucleótidos Antisentido/uso terapéutico; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patología; Proteínas de Unión al ARN/metabolismo; Transducción de Señal/efectos de los fármacos; Tasa de Supervivencia; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas de Unión al ARN / Resistencia a Antineoplásicos / Carcinoma Ductal Pancreático / Imagen Molecular / Proteínas del Tejido Nervioso Tipo de estudio: Diagnostic_studies Idioma: En Revista: Nature Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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