Ternary inclusion complex formation and stabilization of limaprost, a prostaglandin E1 derivative, in the presence of &#945;- and ß-cyclodextrins in the solid state.

Inoue, Yasuo; Iohara, Daisuke; Sekiya, Noboru; Yamamoto, Masanobu; Ishida, Hiroyuki; Sakiyama, Yoko; Hirayama, Fumitoshi; Arima, Hidetoshi; Uekama, Kaneto

Ternary inclusion complex formation and stabilization of limaprost, a prostaglandin E1 derivative, in the presence of α- and ß-cyclodextrins in the solid state.

Inoue, Yasuo; Iohara, Daisuke; Sekiya, Noboru; Yamamoto, Masanobu; Ishida, Hiroyuki; Sakiyama, Yoko; Hirayama, Fumitoshi; Arima, Hidetoshi; Uekama, Kaneto.

Afiliación

Inoue Y; CMC Regulatory and Analytical R&D, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan. Electronic address: ya.inoue@ono.co.jp.
Iohara D; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Sekiya N; Pharmaceutical Development Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Yamamoto M; CMC Strategy Development, Ono Pharmaceutical Co., Ltd., 8-2, Kyutaromachi 1-chome, Chuo-ku, Osaka 541-8564, Japan.
Ishida H; Toray Research Center, Inc., 3-7 Sonoyama 3, Otsu, Shiga 520-8567, Japan.
Sakiyama Y; Toray Research Center, Inc., 3-7 Sonoyama 3, Otsu, Shiga 520-8567, Japan.
Hirayama F; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
Arima H; Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Uekama K; Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.

Int J Pharm ; 509(1-2): 338-347, 2016 Jul 25.

Article en En | MEDLINE | ID: mdl-27286633

Asunto(s)

Alprostadil/análogos & derivados; Alprostadil/química; alfa-Ciclodextrinas/química; beta-Ciclodextrinas/química; Química Farmacéutica/métodos; Cristalización/métodos; Excipientes/química; Liofilización/métodos; Espectroscopía de Resonancia Magnética/métodos; Soluciones Farmacéuticas/química; Solubilidad

Palabras clave

Cyclodextrin; Limaprost; Solid state; Stability; Ternary inclusion complex

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alprostadil / Alfa-Ciclodextrinas / Beta-Ciclodextrinas Idioma: En Revista: Int J Pharm Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos

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