Mechanisms of reoxygenation injury in myocardial infarction: implications of a myoglobin redox cycle.
Biochem Biophys Res Commun
; 160(3): 1162-8, 1989 May 15.
Article
en En
| MEDLINE
| ID: mdl-2730642
ABSTRACT
The addition of ascorbate to ischemic rat hearts prevents the myocardial damage associated with reoxygenation. H2O2 oxidizes myoglobin (Mb+2) to higher oxidation states (Mb+4 and Mb+5) which are rapidly reduced by ascorbate. It is proposed that the operation of a myoglobin redox cycle, in which H2O2 causes the two-electron oxidation of myoglobin, is a critical determinant of reperfusion injury. Conversely, the reduction of myoglobin, in one-electron steps, may represent an essential protective mechanism against such injury in the heart.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión Miocárdica
/
Infarto del Miocardio
/
Mioglobina
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1989
Tipo del documento:
Article