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Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
Shim, Hyeseok; Wu, Chuan; Ramsamooj, Shivan; Bosch, Kaitlyn N; Chen, Zuojia; Emerling, Brooke M; Yun, Jihye; Liu, Hui; Choo-Wing, Rayman; Yang, Zhiwei; Wulf, Gerburg M; Kuchroo, Vijay Kumar; Cantley, Lewis C.
Afiliación
  • Shim H; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065; Biological and Biomedical Sciences Graduate Program, Harvard Medical School, Boston, MA 02115;
  • Wu C; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115;
  • Ramsamooj S; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
  • Bosch KN; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
  • Chen Z; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115;
  • Emerling BM; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
  • Yun J; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
  • Liu H; Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02115.
  • Choo-Wing R; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
  • Yang Z; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;
  • Wulf GM; Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02115.
  • Kuchroo VK; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115;
  • Cantley LC; Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065; lcantley@med.cornell.edu.
Proc Natl Acad Sci U S A ; 113(27): 7596-601, 2016 07 05.
Article en En | MEDLINE | ID: mdl-27313209
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activación de Linfocitos / Fosfotransferasas (Aceptor de Grupo Alcohol) / Complejos Multiproteicos / Serina-Treonina Quinasas TOR / Inflamación Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Activación de Linfocitos / Fosfotransferasas (Aceptor de Grupo Alcohol) / Complejos Multiproteicos / Serina-Treonina Quinasas TOR / Inflamación Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos