Acute pancreatitis and bile duct lesions in rat induced by dibutyltin dichloride.
Exp Pathol
; 36(1): 59-62, 1989.
Article
en En
| MEDLINE
| ID: mdl-2731591
ABSTRACT
After i.v. or i.p. administration of a single dose of dibutyltin dichloride (DBTC) the following changes were observed in pancreas and bile ducts of male rats acute interstitial pancreatitis, enlargement of diameter and destruction of epithelial cells of the bile ducts, increase of serum alkaline phosphatase activity. The effects were dependent on the dose of DBTC (1, 4 or 6 mg/kg body weight), the route of administration and the time after treatment. The pancreatitis induced by DBTC is under further investigation as a model of experimental pancreatitis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Orgánicos de Estaño
/
Páncreas
/
Pancreatitis
/
Conductos Biliares
Límite:
Animals
Idioma:
En
Revista:
Exp Pathol
Año:
1989
Tipo del documento:
Article