Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis.
Wiley Interdiscip Rev Syst Biol Med
; 8(5): 378-401, 2016 09.
Article
en En
| MEDLINE
| ID: mdl-27341633
ABSTRACT
Atherosclerosis is a multifactorial disease that preferentially occurs in arterial regions exposed to d-flow can be used to indicate disturbed flow or disturbed blood flow. The mechanisms by which d-flow induces atherosclerosis involve changes in the transcriptome, methylome, proteome, and metabolome of multiple vascular cells, especially endothelial cells. Initially, we begin with the pathogenesis of atherosclerosis and the changes that occur at multiple levels owing to d-flow, especially in the endothelium. Also, there are a variety of strategies used for the global profiling of the genome, transcriptome, miRNA-ome, DNA methylome, and metabolome that are important to define the biological and pathophysiological mechanisms of endothelial dysfunction and atherosclerosis. Finally, systems biology can be used to integrate these 'omics' datasets, especially those that derive data based on a single animal model, in order to better understand the pathophysiology of atherosclerosis development in a holistic manner and how this integrative approach could be used to identify novel molecular diagnostics and therapeutic targets to prevent or treat atherosclerosis. WIREs Syst Biol Med 2016, 8378-401. doi 10.1002/wsbm.1344 For further resources related to this article, please visit the WIREs website.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Aterosclerosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Wiley Interdiscip Rev Syst Biol Med
Asunto de la revista:
BIOLOGIA
/
BIOTECNOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos