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[Application of Cytogenetic Test for Diagnosis of Bone Marrow Involvement in Patients with Non-Hodgkin's Lymphoma].
Tang, Yin; Wang, Wei; Gao, Li; Sun, Yue; Gao, Ya-Yue; Zhang, Chun-Xia; Gong, Ming; Huang, Fan-Zhou; Li, Zhen-Ling; Ma, Yi-Gai.
Afiliación
  • Tang Y; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Wang W; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Gao L; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Sun Y; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Gao YY; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Zhang CX; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Gong M; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Huang FZ; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Li ZL; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China.
  • Ma YG; Department of Hematology, China-Japan Friendship Hospital, Beijing 100029, China. E-mail: dr_myg@163.com.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 24(3): 727-32, 2016 Jun.
Article en Zh | MEDLINE | ID: mdl-27342499
OBJECTIVE: To investigate the role of cytogenetic analysis in the detection of bone marrow (BM) involvement in patients with non-Hodgkin's lymphoma (NHL). METHODS: The bone marrow samples of 74 patients with NHL were detection by using morphology, cytogenetic test, flow cytometry and molecular biological assay. The detected results of morphology, cytogenetic test, flow cytometry and molecular biological assay alone and thier combined detection were compared, the detective rate and consistencies of the 4 methods were analyzed. RESULTS: The detection rates of BM involvement by using morphology, cytogenetic, flow cytometry, and molecular biological assays were 21.6%, 17.6%, 23.0% and 33.8% respectively. The detective rate was enhanced to 44.6% by combining the 4 methods. Cytogenetic test showed the result consistent with the other methods. CONCLUSION: Although cytogenetic test shows a lower detective rate than the other methods, but in some patients the cytogenetic test can detect the abnormality of bone marrow which can not be detected by other methods alone, the combination test of 4 detection methods can enhance the detectable rate of BM involvement.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Examen de la Médula Ósea / Linfoma no Hodgkin / Análisis Citogenético Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Examen de la Médula Ósea / Linfoma no Hodgkin / Análisis Citogenético Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: China