Mitochondrial stress-induced p53 attenuates HIF-1&#945; activity by physical association and enhanced ubiquitination.

Chowdhury, A Roy; Long, A; Fuchs, S Y; Rustgi, A; Avadhani, N G

Mitochondrial stress-induced p53 attenuates HIF-1α activity by physical association and enhanced ubiquitination.

Chowdhury, A Roy; Long, A; Fuchs, S Y; Rustgi, A; Avadhani, N G.

Afiliación

Chowdhury AR; Department of Biomedical Sciences and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Long A; Division of Gastroenterology, Department of Medicine and Genetics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fuchs SY; Department of Biomedical Sciences and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rustgi A; Division of Gastroenterology, Department of Medicine and Genetics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Avadhani NG; Department of Biomedical Sciences and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Oncogene ; 36(3): 397-409, 2017 01 19.

Article en En | MEDLINE | ID: mdl-27345397

Asunto(s)

Calcineurina/metabolismo; Calcio/metabolismo; ADN Mitocondrial/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Mitocondrias/genética; Proteína p53 Supresora de Tumor/metabolismo; Células A549; Animales; Secuencia de Bases; Células COS; Línea Celular Tumoral; Células HCT116; Humanos; Ratones; Unión Proteica; Ratas; Eliminación de Secuencia; Transducción de Señal; Ubiquitinación

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Mitocondrial / Calcio / Proteína p53 Supresora de Tumor / Calcineurina / Subunidad alfa del Factor 1 Inducible por Hipoxia / Mitocondrias Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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