Th1, Th2 and Th17 Cytokine Profile in Patients with Multiple Sclerosis Following Treatment with Rapamycin.
Iran J Immunol
; 13(2): 141-7, 2016 Jun.
Article
en En
| MEDLINE
| ID: mdl-27350635
ABSTRACT
BACKGROUND:
Management of multiple sclerosis (MS) is based on the usage of immunosuppressive and immune-modulating medications. Cytokines play an important role in the pathogenesis of MS.OBJECTIVE:
To evaluate the effects of rapamycin on the concentrations of Th1/Th2/Th17 serum cytokines in patients with MS.METHODS:
Six patients with relapsing remitting MS as a case group and 6 healthy individuals as a control group were enrolled. The patients have been receiving 2 mg rapamycin daily for 6 months. The individuals in control group received nothing during 6 months of the experiment. Enzyme linked immunosorbent assay (Simultaneous Multi-Analyte ELISA) technique was used for determination of serum concentrations of IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, IFN-γ, TNF-α, G-CSF and TGF-ß before and after therapy with rapamycin.RESULTS:
The mean absorbance of 10 out of the 12 studied cytokines showed reduction after the therapy with rapamycin including IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, IFN-γ and TNF-α. The only statistically significant reduction was observed in the absorbance of IFN-γ (p=0.028). Two cytokines illustrated increase in the patients sera after the therapy, including G-CSF and TGF-ß, but only increase in TGF-ß was statistically significant (p=0.046). None of the studied cytokines in the control group varied significantly after 6 months.CONCLUSION:
Based on the findings of this study, rapamycin has some immunosuppressive effects, such as decreasing IFN -γ, which can improve the quality of life of the patients with multiple sclerosis. Also the increased level of TGF-ß may also have benefits on the disease, which needs further clinical studies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor de Crecimiento Transformador beta
/
Interferón gamma
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Células Th2
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Células TH1
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Sirolimus
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Células Th17
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Esclerosis Múltiple
Aspecto:
Patient_preference
Límite:
Adult
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Iran J Immunol
Año:
2016
Tipo del documento:
Article