Antitumor and immunomodulation activities of polysaccharide from Phellinus baumii.
Int J Biol Macromol
; 91: 1199-205, 2016 Oct.
Article
en En
| MEDLINE
| ID: mdl-27370747
ABSTRACT
A homogeneous polysaccharide (PPB) was purified from fruiting bodies of Phellinus baumii. And in vitro antitumor and immunomodulation activities were investigated on HeLa, SGC-7901 and RAW264.7 cell lines. PPB inhibited the proliferation of HeLa and SGC-7901 cells significantly, and flow cytometric studies revealed that PPB could mediate the cell cycle in the G0/G1 and S phases. Furthermore, PPB could promote the growth and phagocytosis of RAW264.7 cells, activate the secretion of cytokines such as TNF-α and IL-6, which indicated that PPB had low toxicity. The results make PPB as a candidate adjuvant in cancer therapy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Basidiomycota
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Polisacáridos Fúngicos
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Factores Inmunológicos
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Antineoplásicos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Int J Biol Macromol
Año:
2016
Tipo del documento:
Article
País de afiliación:
China