Social disinhibition is a heritable subphenotype of tics in Tourette syndrome.
Neurology
; 87(5): 497-504, 2016 Aug 02.
Article
en En
| MEDLINE
| ID: mdl-27371487
ABSTRACT
OBJECTIVE:
To identify heritable symptom-based subtypes of Tourette syndrome (TS).METHODS:
Forty-nine motor and phonic tics were examined in 3,494 individuals (1,191 TS probands and 2,303 first-degree relatives). Item-level exploratory factor and latent class analyses (LCA) were used to identify tic-based subtypes. Heritabilities of the subtypes were estimated, and associations with clinical characteristics were examined.RESULTS:
A 6-factor exploratory factor analysis model provided the best fit, which paralleled the somatotopic representation of the basal ganglia, distinguished simple from complex tics, and separated out socially disinhibited and compulsive tics. The 5-class LCA model best distinguished among the following groups unaffected, simple tics, intermediate tics without social disinhibition, intermediate with social disinhibition, and high rates of all tic types. Across models, a phenotype characterized by high rates of social disinhibition emerged. This phenotype was associated with increased odds of comorbid psychiatric disorders, in particular, obsessive-compulsive disorder and attention-deficit/hyperactivity disorder, earlier age at TS onset, and increased tic severity. The heritability estimate for this phenotype based on the LCA was 0.53 (SE 0.08, p 1.7 × 10(-18)).CONCLUSIONS:
Expanding on previous modeling approaches, a series of TS-related phenotypes, including one characterized by high rates of social disinhibition, were identified. These phenotypes were highly heritable and may reflect underlying biological networks more accurately than traditional diagnoses, thus potentially aiding future genetic, imaging, and treatment studies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Social
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Síndrome de Tourette
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Tics
/
Inhibición Psicológica
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Región como asunto:
America do norte
/
Europa
Idioma:
En
Revista:
Neurology
Año:
2016
Tipo del documento:
Article
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA