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Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells.
Xiong, Ke; Wei, Wei; Jin, Yongjie; Wang, Shumin; Zhao, Dongxu; Wang, Shuang; Gao, Xiaoyong; Qiao, Chenmeng; Yue, Hua; Ma, Guanghui; Xie, Hai-Yan.
Afiliación
  • Xiong K; School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
  • Wei W; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
  • Jin Y; School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
  • Wang S; School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
  • Zhao D; School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
  • Wang S; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
  • Gao X; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
  • Qiao C; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
  • Yue H; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
  • Ma G; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
  • Xie HY; School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China. hyanxie@bit.edu.cn.
Adv Mater ; 28(36): 7929-7935, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27376951
ABSTRACT
A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Separación Celular / Materiales Biomiméticos / Magnetosomas / Células Neoplásicas Circulantes Límite: Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: ALEMANHA / ALEMANIA / DE / DEUSTCHLAND / GERMANY
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Separación Celular / Materiales Biomiméticos / Magnetosomas / Células Neoplásicas Circulantes Límite: Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: ALEMANHA / ALEMANIA / DE / DEUSTCHLAND / GERMANY