Post progression survival analysis of metastatic gastric and gastroesophageal junction cancer patients after second-line treatment.
Acta Gastroenterol Belg
; 79(2): 211-5, 2016.
Article
en En
| MEDLINE
| ID: mdl-27382940
ABSTRACT
PURPOSE:
The aim of this study was to define the factors that -affect response and post-progression survival of metastatic gastric cancer (MGC) and gastroesophageal junction cancer (GEJ) -patients treated with second-line chemotherapy.METHODS:
We retrospectively reviewed the data of 59 patients with MGC or GEJ adenocarcinoma who received second-line treatment.RESULTS:
The median age was 54 years old (26-77). Response to second-line treatment was strongly associated with disease control with first-line treatment (p <â0.01). Median progression-free survival (PFS), overall survival (OS) and post-progression survival (PPS) were 3.2 (95% CIâ 2.63-3.80), 6.5 (95% CIâ 3.78-9.35) and 2.7 months (95% CIâ 1.89-3.68), respectively. PFS (râ=â0.55, pâ<â0.01) and PPS (râ=â0.89, pâ<â0.01) were correlated with OS. Response to second-line treatment was independently related to PFS (HRâ 0.12 95%CIâ 0.53-0.26, pâ<â0.001). Having an ECOG 0 performance status (HRâ 0.42â; 95%CIâ 0.21-0.86, pâ=â0.02) and response to second-line therapy (HRâ 0.47â; 95%CIâ 0.25-0.85, pâ=â0.01) were independently associated with OS.CONCLUSION:
PPS and PFS were correlated with OS after second-line treatment of MGC. Response to second-line treatment prolonged OS by increasing PFS, and having an ECOG 0 PS prolonged OS by increasing PPS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Peritoneales
/
Neoplasias Gástricas
/
Adenocarcinoma
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Unión Esofagogástrica
/
Recurrencia Local de Neoplasia
/
Antineoplásicos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Gastroenterol Belg
Año:
2016
Tipo del documento:
Article
País de afiliación:
Turquía