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Changes in Behavior and Blood Corticosterone Level in Male and Female Rats after Single Administration of Obestatin Fragment 1-4.
Motorykina, E S; Khirazova, E A; Maslova, M V; Graf, A V; Maklakova, A S; Bayzhumanov, A A; Kurko, O D; Andreeva, L A; Sokolova, N A; Myasoedov, N F; Kamenskii, A A.
Afiliación
  • Motorykina ES; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia. motorykina.katerina@gmail.com.
  • Khirazova EA; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Maslova MV; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Graf AV; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Maklakova AS; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Bayzhumanov AA; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Kurko OD; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Andreeva LA; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Sokolova NA; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Myasoedov NF; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Kamenskii AA; Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med ; 161(2): 218-20, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27383154
ABSTRACT
Single administration of the obestatin fragment 1-4 (300 nmol/kg) to male Wistar rats produced a significant weight loss in male rats on observation days 5-8, while in female rats only on day 8. In addition, males demonstrated decreased risk factor in the elevated plus-maze test, but no effect of the preparation on behavior of female rats was revealed. Obestatin fragment 1-4 had no effect on corticosterone level 1 week after single administration in both females and male rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Fármacos Antiobesidad Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2016 Tipo del documento: Article País de afiliación: Rusia
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Fármacos Antiobesidad Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2016 Tipo del documento: Article País de afiliación: Rusia