Local-anesthetic like inhibition of the cardiac sodium channel Nav1.5 &#945;-subunit by 5-HT3 receptor antagonists.

Van't Klooster, Mariet P; Foadi, Nilufar; Hage, Axel; Stoetzer, Carsten; Wegner, Florian; Eberhardt, Mirjam; Leffler, Andreas

Local-anesthetic like inhibition of the cardiac sodium channel Nav1.5 α-subunit by 5-HT3 receptor antagonists.

Van't Klooster, Mariet P; Foadi, Nilufar; Hage, Axel; Stoetzer, Carsten; Wegner, Florian; Eberhardt, Mirjam; Leffler, Andreas.

Afiliación

Van't Klooster MP; Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Foadi N; Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Hage A; Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Stoetzer C; Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Wegner F; Department of Neurology, Hannover Medical School, Hannover, Germany.
Eberhardt M; Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Leffler A; Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany. Electronic address: leffler.andreas@mh-hannover.de.

Eur J Pharmacol ; 789: 119-126, 2016 Oct 15.

Article en En | MEDLINE | ID: mdl-27401036

Asunto(s)

Anestésicos Locales/farmacología; Miocardio/metabolismo; Canal de Sodio Activado por Voltaje NAV1.5/metabolismo; Receptores de Serotonina 5-HT3/metabolismo; Antagonistas del Receptor de Serotonina 5-HT3/farmacología; Bloqueadores de los Canales de Sodio/farmacología; Sinergismo Farmacológico; Células HEK293; Humanos; Mutación; Canal de Sodio Activado por Voltaje NAV1.5/genética; Neuronas/efectos de los fármacos; Neuronas/metabolismo; Sodio/metabolismo

Palabras clave

5-HT(3) receptor antagonist; Granisetron; Local anesthetic; Nav1.5; Ondansetron; Tropisetron

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Sodio / Receptores de Serotonina 5-HT3 / Antagonistas del Receptor de Serotonina 5-HT3 / Canal de Sodio Activado por Voltaje NAV1.5 / Anestésicos Locales / Miocardio Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos

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