Novel myosin-based therapies for congenital cardiac and skeletal myopathies.
J Med Genet
; 53(10): 651-4, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-27412953
ABSTRACT
The dysfunction in a number of inherited cardiac and skeletal myopathies is primarily due to an altered ability of myofilaments to generate force and motion. Despite this crucial knowledge, there are, currently, no effective therapeutic interventions for these diseases. In this short review, we discuss recent findings giving strong evidence that genetically or pharmacologically modulating one of the myofilament proteins, myosin, could alleviate the muscle pathology. This should constitute a research and clinical priority.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Miosinas
/
Enfermedades Musculares
/
Cardiomiopatías
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Med Genet
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido