ESR evidence for the oxidative cleavage of gentisic acid in basic aqueous solution.
Redox Rep
; 1(3): 219-23, 1995 May.
Article
en En
| MEDLINE
| ID: mdl-27414279
ABSTRACT
The oxidative cleavage of 2,5-dihydroxybenzoic acid (gentisic acid), presumably into maleylpyruvate in basic aqueous solution has been shown by ESR spectra of semiquinonic radicals bearing a methylenic group. One of these radicals has been unambiguously attributed to 2,4,5-trihydroxyphenylacetic acid semiquinonic radical. The formation of an hydroxylated homogentisic acid from gentisic acid (a metabolite of aspirin) is of particular importance in the treatment of alkaptonuria and related inflammatory arthritis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Redox Rep
Asunto de la revista:
BIOQUIMICA
/
METABOLISMO
Año:
1995
Tipo del documento:
Article
País de afiliación:
Francia