[Myeloperoxidase activity in blood plasma as a criterion of therapy for patients with cardiovascular disease]. / Aktivnost' mieloperoksidazy v plazme krovi kak kriterii éffektivnosti lecheniia patsientov s serdechno-sosudistymi zabolevaniiami.
Biomed Khim
; 62(3): 318-24, 2016 Mar.
Article
en Ru
| MEDLINE
| ID: mdl-27420626
ABSTRACT
A significant increase in the myeloperoxidase (MPO) activity has been found in plasma of patients with stable angina and with acute coronary syndrome (ACS) in comparison with the control group. MPO concentration was significantly increased in plasma of ACS patients. Reduced MPO activity in the treated ACS patients correlated with a favorable outcome of the disease. Generally, changes in plasma MPO concentration coincided with changes in lactoferrin concentration thus confirming the role of neutrophil degranulation in the increase of plasma concentrations of these proteins. The increase in MPO activity was obviously determined by modification of the MPO protein caused by reactive oxygen species and halogen in the molar ratio of 1 25 and 1 50. The decrease in plasma MPO activity may be associated with increased plasma concentrations of the physiological inhibitor of its activity, ceruloplasmin, and also with modification of the MPO protein with reactive oxygen species and halogen at their molar ratio of 1 100 and higher. Thus, MPO activity may be used for evaluation of effectiveness of the treatment of cardiovascular diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Peroxidasa
/
Síndrome Coronario Agudo
/
Angina Estable
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Biomed Khim
Año:
2016
Tipo del documento:
Article
País de afiliación:
Belarús