A Physiologically Based Pharmacokinetic Model for Ganciclovir and Its Prodrug Valganciclovir in Adults and Children.

Lukacova, V; Goelzer, P; Reddy, M; Greig, G; Reigner, B; Parrott, N

Lukacova, V; Goelzer, P; Reddy, M; Greig, G; Reigner, B; Parrott, N.

Afiliación

Lukacova V; Simulations Plus, Inc., 42505 10th Street West, Lancaster, California, 93534, USA.
Goelzer P; Teva Pharmaceuticals, West Chester, Pennsylvania, 19380, USA.
Reddy M; Array BioPharma, Boulder, Colorado, 80301, USA.
Greig G; Clinical Pharmacology, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Reigner B; Clinical Pharmacology, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Parrott N; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland. neil_john.parrott@roche.com.

AAPS J ; 18(6): 1453-1463, 2016 11.

Article en En | MEDLINE | ID: mdl-27450227

Asunto(s)

Antivirales/farmacocinética; Ganciclovir/análogos & derivados; Ganciclovir/farmacocinética; Modelos Biológicos; Profármacos/farmacocinética; Adulto; Animales; Niño; Ganciclovir/sangre; Humanos; Valganciclovir

Palabras clave

esterases; pediatrics; permeability limited distribution; physiologically based pharmacokinetic models

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Profármacos / Ganciclovir / Modelos Biológicos Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Child / Humans Idioma: En Revista: AAPS J Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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