Development of carvedilol-cyclodextrin inclusion complexes using fluid-bed granulation: a novel solid-state complexation alternative with technological advantages.

Alonso, Ellen C P; Riccomini, Karina; Silva, Luis Antônio D; Galter, Daniela; Lima, Eliana M; Durig, Thomas; Taveira, Stephania F; Martins, Felipe Terra; Cunha-Filho, Marcílio S S; Marreto, Ricardo N

Alonso, Ellen C P; Riccomini, Karina; Silva, Luis Antônio D; Galter, Daniela; Lima, Eliana M; Durig, Thomas; Taveira, Stephania F; Martins, Felipe Terra; Cunha-Filho, Marcílio S S; Marreto, Ricardo N.

Afiliación

Alonso EC; Laboratory of Pharmaceutical Technology, Federal University of Goiás, Goiânia, GO, Brazil.
Riccomini K; Pharmaceutical Application Laboratory, Ashland Specialty Ingredients, São Paulo, SP, Brazil.
Silva LA; Laboratory of Pharmaceutical Technology, Federal University of Goiás, Goiânia, GO, Brazil.
Galter D; Pharmaceutical Application Laboratory, Ashland Specialty Ingredients, São Paulo, SP, Brazil.
Lima EM; Laboratory of Pharmaceutical Technology, Federal University of Goiás, Goiânia, GO, Brazil.
Durig T; Pharmaceutical and Nutrition Specialties R&D, Ashland Specialty Ingredients, Wilmington, DE, USA.
Taveira SF; Laboratory of Pharmaceutical Technology, Federal University of Goiás, Goiânia, GO, Brazil.
Martins FT; Chemical Institute, Federal University of Goiás, Goiânia, GO, Brazil.
Cunha-Filho MS; Laboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
Marreto RN; Laboratory of Pharmaceutical Technology, Federal University of Goiás, Goiânia, GO, Brazil. ricardomarreto@ufg.br.

J Pharm Pharmacol ; 68(10): 1299-309, 2016 Oct.

Article en En | MEDLINE | ID: mdl-27465985

Asunto(s)

Carbazoles/química; Propanolaminas/química; beta-Ciclodextrinas/química; gamma-Ciclodextrinas/química; Rastreo Diferencial de Calorimetría/métodos; Carvedilol; Composición de Medicamentos/métodos; Tamaño de la Partícula; Solubilidad; Espectroscopía Infrarroja por Transformada de Fourier/métodos; Difracción de Rayos X/métodos

Palabras clave

carvedilol; hydroxypropyl-ß-cyclodextrin; hydroxypropyl-Î³-cyclodextrin; solid-state inclusion complex

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Propanolaminas / Carbazoles / Beta-Ciclodextrinas / Gamma-Ciclodextrinas Idioma: En Revista: J Pharm Pharmacol Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido

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