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Abnormal cortical synaptic plasticity in minimal hepatic encephalopathy.
Golaszewski, Stefan; Langthaler, Patrick B; Schwenker, Kerstin; Florea, Cristina; Christova, Monica; Brigo, Francesco; Trinka, Eugen; Nardone, Raffaele.
Afiliación
  • Golaszewski S; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
  • Langthaler PB; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
  • Schwenker K; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
  • Florea C; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
  • Christova M; Department of Physiology, Medical University of Graz, Graz, Austria.
  • Brigo F; Department of Neurology, Franz Tappeiner Hospital, Merano, Italy; Department of Neurological and Movement Sciences, Section of Clinical Neurology, University of Verona, Verona, Italy.
  • Trinka E; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.
  • Nardone R; Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria; Department of Neurology, Franz Tappeiner Hospital, Merano, Italy. Electronic address: raffaele.nardone@asbmeran-o.it.
Brain Res Bull ; 125: 200-4, 2016 07.
Article en En | MEDLINE | ID: mdl-27475415
Minimal hepatic encephalopathy (MHE) represents the earliest stage of hepatic encephalopathy (HE). MHE is characterized by cognitive function impairment in the domains of attention, vigilance and integrative function, while obvious clinical manifestations are lacking. In the present study, we aimed at assessing whether subjects with MHE showed alterations in synaptic plasticity within the motor cortex. Previous findings suggest that learning in human motor cortex occurs through long-term potentiation (LTP)-like mechanisms. We employed therefore the paired associative stimulation (PAS) protocol by transcranial magnetic stimulation (TMS), which is able to induce LTP-like effects in the motor cortex of normal subjects. Fifteen patients with MHE and 15 age- and sex-matched cirrhotic patients without MHE were recruited. PAS consisted of 180 electrical stimuli of the right median nerve paired with a single TMS over the hotspot of right abductor pollicis brevis (APB) at an ISI of 25ms (PAS25). We measured motor evoked potentials (MEPs) before and after each intervention for up to 30min. In healthy subjects the PAS25 protocol was followed by a significant increase of the MEP amplitude. On the contrary, in patients with MHE the MEP amplitude was slightly reduced after PAS. These findings demonstrated that associative sensorimotor plasticity, an indirect probe for motor learning, is impaired in MHE patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalopatía Hepática / Potenciación a Largo Plazo / Corteza Motora Tipo de estudio: Guideline Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Brain Res Bull Año: 2016 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalopatía Hepática / Potenciación a Largo Plazo / Corteza Motora Tipo de estudio: Guideline Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Brain Res Bull Año: 2016 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos