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Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons.
Jo, Junghyun; Xiao, Yixin; Sun, Alfred Xuyang; Cukuroglu, Engin; Tran, Hoang-Dai; Göke, Jonathan; Tan, Zi Ying; Saw, Tzuen Yih; Tan, Cheng-Peow; Lokman, Hidayat; Lee, Younghwan; Kim, Donghoon; Ko, Han Seok; Kim, Seong-Oh; Park, Jae Hyeon; Cho, Nam-Joon; Hyde, Thomas M; Kleinman, Joel E; Shin, Joo Heon; Weinberger, Daniel R; Tan, Eng King; Je, Hyunsoo Shawn; Ng, Huck-Hui.
Afiliación
  • Jo J; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.
  • Xiao Y; Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
  • Sun AX; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; National Neuroscience Institute, 20 College Road, Singapore 169856, Singapore.
  • Cukuroglu E; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.
  • Tran HD; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.
  • Göke J; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.
  • Tan ZY; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore.
  • Saw TY; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.
  • Tan CP; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.
  • Lokman H; Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Lee Y; Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
  • Kim D; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Ko HS; Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Kim SO; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
  • Park JH; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
  • Cho NJ; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, Korea.
  • Hyde TM; The Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Kleinman JE; The Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Shin JH; The Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA.
  • Weinberger DR; The Lieber Institute for Brain Development, 855 North Wolfe Street, Baltimore, MD 21205, USA; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of
  • Tan EK; National Neuroscience Institute, 20 College Road, Singapore 169856, Singapore.
  • Je HS; Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic address: shawn.je@duke-nus.edu.sg.
  • Ng HH; Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singa
Cell Stem Cell ; 19(2): 248-257, 2016 08 04.
Article en En | MEDLINE | ID: mdl-27476966
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mesencéfalo / Organoides / Células Madre Pluripotentes / Neuronas Dopaminérgicas / Melaninas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Stem Cell Año: 2016 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mesencéfalo / Organoides / Células Madre Pluripotentes / Neuronas Dopaminérgicas / Melaninas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Stem Cell Año: 2016 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos