Incides of lipid peroxidation in patients with hypercholesterolemia and hypertriglyceridemia.
Wien Klin Wochenschr
; 101(12): 425-8, 1989 Jun 09.
Article
en En
| MEDLINE
| ID: mdl-2750170
ABSTRACT
Peroxidation of lipoproteins has received attention recently in connection with its possible initiation and propagation of atherosclerosis. We studied indices of lipid peroxidation in plasma of 30 patients with either hypercholesterolemia or both hypercholesterolemia and hypertriglyceridemia, and compared them with those of 19 healthy subjects. In the patients lipid hydroperoxides measured both iodometrically and as thiobarbituric acid-reactive substances (TBA-RS) were significantly increased, while concentrations of thiol groups remained unchanged. There was no correlation between concentrations of hydroperoxides and TBA-RS, possibly because the two methods assessed different breakdown products of lipid peroxidation. Lipid hydroperoxide levels, but not those of TBA-RS were correlated with LDL-cholesterol and triglyceride levels. In 6 patients administration of vitamin E at a daily dosage of 300 mg for 4 to 6 weeks depressed elevated hydroperoxides by 33%, and TBA-RS by 44% on average.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Peroxidación de Lípido
/
Hiperlipoproteinemias
/
Lipoproteínas
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Wien Klin Wochenschr
Año:
1989
Tipo del documento:
Article
País de afiliación:
Polonia