Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone.

McLaughlin, Gavin; Morris, Noreen; Kavanagh, Pierce V; Power, John D; Dowling, Geraldine; Twamley, Brendan; O'Brien, John; Talbot, Brian; Walther, Donna; Partilla, John S; Baumann, Michael H; Brandt, Simon D

McLaughlin, Gavin; Morris, Noreen; Kavanagh, Pierce V; Power, John D; Dowling, Geraldine; Twamley, Brendan; O'Brien, John; Talbot, Brian; Walther, Donna; Partilla, John S; Baumann, Michael H; Brandt, Simon D.

Afiliación

McLaughlin G; Department of Life and Physical Sciences, School of Science, Athlone Institute of Technology, Athlone, Co. Westmeath, Ireland.
Morris N; Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland.
Kavanagh PV; Department of Life and Physical Sciences, School of Science, Athlone Institute of Technology, Athlone, Co. Westmeath, Ireland.
Power JD; Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland.
Dowling G; Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland.
Twamley B; Forensic Science Ireland, Garda HQ, Dublin 8, Ireland.
O'Brien J; Department of Pharmacology and Therapeutics, School of Medicine, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland.
Talbot B; School of Chemistry, Trinity College Dublin, Dublin 2, Ireland.
Walther D; School of Chemistry, Trinity College Dublin, Dublin 2, Ireland.
Partilla JS; School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin 2, Ireland.
Baumann MH; Designer Drug Research Unit of the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
Brandt SD; Designer Drug Research Unit of the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

Drug Test Anal ; 9(3): 358-368, 2017 Mar.

Article en En | MEDLINE | ID: mdl-27524685

Asunto(s)

Metanfetamina/análogos & derivados; Psicotrópicos/química; Psicotrópicos/farmacología; Animales; Encéfalo/efectos de los fármacos; Encéfalo/metabolismo; Cristalografía por Rayos X; Proteínas de Transporte de Dopamina a través de la Membrana Plasmática/antagonistas & inhibidores; Proteínas de Transporte de Dopamina a través de la Membrana Plasmática/metabolismo; Isomerismo; Masculino; Metanfetamina/síntesis química; Metanfetamina/química; Metanfetamina/farmacología; Modelos Moleculares; Proteínas de Transporte de Noradrenalina a través de la Membrana Plasmática/antagonistas & inhibidores; Proteínas de Transporte de Noradrenalina a través de la Membrana Plasmática/metabolismo; Psicotrópicos/síntesis química; Ratas; Ratas Sprague-Dawley; Proteínas de Transporte de Serotonina en la Membrana Plasmática/metabolismo; Inhibidores Selectivos de la Recaptación de Serotonina/síntesis química; Inhibidores Selectivos de la Recaptación de Serotonina/química; Inhibidores Selectivos de la Recaptación de Serotonina/farmacología; Sinaptosomas/efectos de los fármacos; Sinaptosomas/metabolismo

Palabras clave

chemistry; mephedrone; mexedrone; new psychoactive substances; psychostimulants

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicotrópicos / Metanfetamina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Drug Test Anal Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido

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