C-8-Selective Allylation of Quinoline: A Case Study of ß-Hydride vs ß-Hydroxy Elimination.
Org Lett
; 18(17): 4198-201, 2016 09 02.
Article
en En
| MEDLINE
| ID: mdl-27533734
ABSTRACT
An unprecedented C(8)-H bond allylation of quinoline with allyl carbonate and allyl alcohol catalyzed by Cp*Co(III) using a traceless directing group via ß-oxygen and ß-hydroxy elimination is described. This site-selective allylation reaction proceeds smoothly with various functional group tolerance including quinoxaline and phenanthridine. Under the nonoxidative reaction conditions, the difference in selectivity between Rh(III) and Co(III), which proceeds through ß-hydride and ß-hydroxy elimination using allyl alcohol, is shown for the first time.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
India