Your browser doesn't support javascript.
loading
Characteristics of Delayed Thyroid Stimulating Hormone Elevation in Neonatal Intensive Care Unit Newborns.
Zung, Amnon; Yehieli, Arie; Blau, Ayala; Almashanu, Shlomo.
Afiliación
  • Zung A; Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel; Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address: amnon.zung@gmail.com.
  • Yehieli A; Gamidor Diagnostics, Petach Tikva, Israel.
  • Blau A; The National Center for Newborn Screening, Ministry of Health, Tel-HaShomer, Israel.
  • Almashanu S; The National Center for Newborn Screening, Ministry of Health, Tel-HaShomer, Israel.
J Pediatr ; 178: 135-140.e1, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27546202
OBJECTIVES: To elucidate the incidence, clinical characteristics, and short-term outcome of delayed thyroid stimulating hormone (TSH) elevation (dTSH) in a large cohort of newborns admitted to the neonatal intensive care unit. STUDY DESIGN: Data were gathered from a cohort of 13 201 newborns admitted to the neonatal intensive care unit born between January 1, 2008, and October 31, 2014, who underwent TSH measurements because of low T4 levels on the second screen. The data from the newborn screening program included gestational age, birth weight (BW), T4 levels, and short-term outcome. RESULTS: Of 13 201 newborns, 333 (1:40) presented with dTSH (TSH >15 IU/L). dTSH had a peak proportion at gestational age of 37-39 weeks, and 66% of the patients had BW >1500 g. T4 levels in the 333 patients were negatively correlated with TSH levels (R = -0.505; P < .001), and significantly lower than levels in the other newborns: 5.9 ± 2.8 vs 7.6 ± 1.7 µg/dL; P < .001. TSH levels in dTSH newborns were already higher on the initial screen compared with the other newborns: 8.3 ± 5.2 vs 4.2 ± 3.7 IU/L; P < .001. Fifty-eight percent of 193 patients with dTSH were started on levothyroxine treatment. CONCLUSIONS: dTSH has a higher incidence than previously reported, especially among newborns with BW >1500 g. Relatively high TSH and low T4 levels on the initial and second screen respectively are predictors for dTSH. Levothyroxine treatment is required in most cases.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirotropina / Tamizaje Neonatal / Hipotiroidismo Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirotropina / Tamizaje Neonatal / Hipotiroidismo Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: J Pediatr Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos