Your browser doesn't support javascript.
loading
Necrotizing granulomatous inflammation of the glans penis.
Christodoulidou, Michelle; Bunker, Christopher B; Trevisan, Giorgia; Muneer, Asif.
Afiliación
  • Christodoulidou M; Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.
  • Bunker CB; Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK.
  • Trevisan G; Department of Pathology, University College London Hospitals NHS Foundation Trust, London, UK.
  • Muneer A; Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK.
BMJ Case Rep ; 20162016 Aug 24.
Article en En | MEDLINE | ID: mdl-27558192
ABSTRACT
We describe the case of a 73-year-old man who presented with a 10-month history of an ulcerating lesion on the glans penis. Initially this was thought to be an invasive squamous cell carcinoma but a biopsy showed histological features consistent with necrotizing granulomatous inflammation. Extensive serological, immunological and microbiological tests only showed a positive antinuclear and perinuclear antineutrophil cytoplasmic antibodies indicating a possible autoimmune aetiology but an underlying systemic cause was not identified. Treatment with oral corticosteroids limited the inflammatory process but due to the gross destruction of the glans penis, he still required a glansectomy and split-skin graft reconstruction from which he recovered well. Although this patient ultimately required surgery for this rare presentation, this case highlights the differential diagnosis of penile ulceration (that transcends neoplasia) and the importance of performing and interpreting penile biopsies before undertaking potentially mutilating definitive surgery.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pene / Balanitis / Granuloma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: BMJ Case Rep Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pene / Balanitis / Granuloma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: BMJ Case Rep Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido