Pharmacological analysis of the cardiac sympatho-inhibitory actions of moxonidine and agmatine in pithed spontaneously hypertensive rats.
Eur J Pharmacol
; 791: 25-36, 2016 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-27565220
ABSTRACT
This study shows that in spontaneously hypertensive rats (SHR) of 14-weeks-old, the sympathetically-induced, but not noradrenaline-induced tachycardic response are higher than age-matched Wistar normotensive rats. Furthermore, in SHR the sympathetically-induced tachycardic response was (1) unaffected by moxonidine (3µg/kgmin); (2) partially inhibited by B-HT 933 (30µg/kgmin), both at the lowest doses; and (3) completely inhibited by the highest doses of B-HT 933 (100µg/kgmin), moxonidine (10µg/kgmin) or agmatine (1000 and 3000µg/kgmin) while the noradrenaline-induced tachycardic responses remained unaffected by the above compounds, except by 3000µg/kgmin agmatine. In SHR, 300µg/kg rauwolscine failed to block the sympatho-inhibition to 100µg/kgmin B-HT 933 or 10µg/kgmin moxonidine, but 1000µg/kg rauwolscine abolished, partially antagonized, and did not modify the sympatho-inhibition to the highest doses of B-HT 933, moxonidine, and agmatine, respectively, 3000µg/kg AGN 192403 or 300µg/kg BU224 given alone had no effect in the moxonidine- or agmatine-induced sympatho-inhibition, and the combination rauwolscine plus AGN 192403 but not plus BU224, abolished the sympatho-inhibition to the highest doses of moxonidine and agmatine. In conclusion, the sympathetically-induced tachycardic responses in SHR are inhibited by moxonidine and agmatine. The inhibition of moxonidine is mainly mediated by prejunctional α2-adrenoceptors and to a lesser extent by I1-imidazoline receptors, while the inhibition of agmatine is mediated by prejunctional α2-adrenoceptors and I1-imidazoline receptors at the same extent. Notwithstanding, the inhibitory function of α2-adrenoceptors seems to be altered in SHR compared with Wistar normotensive rats.
Palabras clave
(±)-noradrenaline bitartrate salt (PubChem CID: 5813); AGN 192403 hydrochloride (PubChem CID: 11957452); Agmatine; Agmatine sulfate salt (PubChem CID: 2794990); B-HT 933 dihydrochloride (PubChem CID: 169743); BU224 hydrochloride (PubChem CID: 11957470); Hypertension; I(1)-imidazoline receptor; Moxonidine; desipramine hydrochloride (PubChem CID: 65327); gallamine triethiodide (PubChem CID: 6172); moxonidine hydrochloride (PubChem CID: 11231255); rauwolscine hydrochloride (PubChem CID: 197067); α(2)-adrenoceptor
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Simpático
/
Agmatina
/
Corazón
/
Imidazoles
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
2016
Tipo del documento:
Article
País de afiliación:
México