Involvement of ESE-3, epithelial-specific ETS factor family member 3, in transactivation of the ABCB1 gene via pregnane X receptor in intestine-derived LS180 cells but not in liver-derived HepG2 cells.

Kameyama, Naoya; Kobayashi, Kaoru; Shimizu, Shoko; Yamasaki, Yuki; Endo, Mika; Hashimoto, Mari; Furihata, Tomomi; Chiba, Kan

Kameyama, Naoya; Kobayashi, Kaoru; Shimizu, Shoko; Yamasaki, Yuki; Endo, Mika; Hashimoto, Mari; Furihata, Tomomi; Chiba, Kan.

Afiliación

Kameyama N; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Kobayashi K; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan. Electronic address: kaoruk@faculty.chiba-u.jp.
Shimizu S; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Yamasaki Y; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Endo M; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Hashimoto M; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Furihata T; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Chiba K; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

Drug Metab Pharmacokinet ; 31(5): 340-348, 2016 Oct.

Article en En | MEDLINE | ID: mdl-27567379

Asunto(s)

Hígado/metabolismo; Receptores de Esteroides/genética; Factores de Transcripción/genética; Activación Transcripcional/genética; Subfamilia B de Transportador de Casetes de Unión a ATP/genética; Línea Celular Tumoral; Genes Reporteros/genética; Células Hep G2; Factor Nuclear 4 del Hepatocito/genética; Humanos; Hígado/efectos de los fármacos; Mutación/efectos de los fármacos; Mutación/genética; Receptor X de Pregnano; ARN Mensajero/genética; Rifampin/farmacología; Activación Transcripcional/efectos de los fármacos

Palabras clave

ABCB1; CYP3A4; Induction; Pregnane X receptor; Rifampicin; Transcription

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Receptores de Esteroides / Activación Transcripcional / Hígado Límite: Humans Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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