Dataset of liver proteins of eu- and hypothyroid rats affected in abundance by any of three factors: in vivo exposure to hexabromocyclododecane (HBCD), thyroid status, gender differences.
Data Brief
; 8: 1344-7, 2016 Sep.
Article
en En
| MEDLINE
| ID: mdl-27579339
ABSTRACT
Male Wistar rats with different thyroid status (eu-, hypothyroid) were exposed to 0, 3 or 30 mg/kg body weight of the flame retardant HBCD for 7 days and obtained data compared with a previous study in females, "Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats" (Miller et al., 2016) [1]. Specifically, proteomic investigation of liver protein patterns obtained by 2D-DIGE was performed and differences between animals groups recorded, based on the factors exposure, thyroid status and gender. All proteins with significantly changed abundance in any of these comparisons were identified by mass spectrometry. General, hormone and proteomic data of both the present and the previous studies are discussed in Miller et al. (2016) [1] and in "Gender specific differences in the liver proteome of rats exposed to hexabromocyclododecane (HBCD)" Miller et al. (2016) [2].
A1AT_RAT, Alpha-1-antiproteinase; ACOX1_RAT, Peroxisomal acyl-coenzyme A oxidase 1; AGT2_RAT, Alanineglyoxylate aminotransferase 2_mitochondrial; AK1D1_RAT, 3-oxo-5-beta-steroid 4-dehydrogenase; AL1B1_RAT, Aldehyde dehydrogenase X_mitochondrial; BHMT1_RAT, Betainehomocysteine S-methyltransferase 1; CAH3_RAT, Carbonic anhydrase 3; DOPD_RAT, D-dopachrome decarboxylase; FABPL_RAT, Fatty acid-binding protein_liver; FRIL1_RAT, Ferritin light chain 1; GRP78_RAT, 78 kDa glucose-regulated protein; GSTA1_RAT, Glutathione S-transferase alpha-1; GSTA2_RAT, Glutathione S-transferase alpha-2; GSTA3_RAT, Glutathione S-transferase alpha-3; GSTP1_RAT, Glutathione S-transferase P; Gender-specific effects; HBA_RAT, Hemoglobin subunit alpha-1/2; HBCD; HPT_RAT, Haptoglobin; Hypothyroidism; K2C8_RAT, Keratin_type II cytoskeletal 8; KNT2_RAT, T-kininogen 2; Liver; M2GD_RAT, Dimethylglycine dehydrogenase_mitochondrial; PON1_RAT, Serum paraoxonase/arylesterase 1; PON3_RAT, Serum paraoxonase/lactonase 3; PRDX3_RAT, Thioredoxin-dependent peroxide reductase_mitochondrial; Proteomics; RD23B_RAT, UV excision repair protein RAD23 homolog B; RET1_RAT, Retinol-binding protein 1; Rat; SARDH_RAT, Sarcosine dehydrogenase_mitochondrial; SPA3N_RAT, Serine protease inhibitor A3N; UB2D2_RAT, Ubiquitin-conjugating enzyme E2 D2
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Aspecto:
Determinantes_sociais_saude
Idioma:
En
Revista:
Data Brief
Año:
2016
Tipo del documento:
Article
País de afiliación:
Austria