[Oligodendroglioma with neuronal differentiation in an 8-month-old African hedgehog (Atelerix albiventris)]. / Oligodendrogliom mit neuronaler Differenzierung bei einem 8 Monate alten Afrikanischen Weißbauchigel (Atelerix albiventris).
Tierarztl Prax Ausg K Kleintiere Heimtiere
; 44(5): 348-354, 2016 Oct 12.
Article
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| MEDLINE
| ID: mdl-27595798
ABSTRACT
An 8-month-old, male African hedgehog clinically displayed a wobbly walk, anuria, inappetence and apathy, whereupon the suspected diagnosis wobbly hedgehog syndrome was made. After exacerbation, the hedgehog was euthanized. Histologically, a tumour mainly consisting of medium-sized, oval tumour cells and a smaller number of spindeloid cells was found in the cerebrum. The tumour contained neuropil islets and extracellular myxoid material. Immunohistochemically, the tumour cells expressed oligodendroglial (neurite outgrowth inhibitor, Nogo-A; oligodendrocyte transcription factor, Olig-2) and neuronal (neuron-specific enolase, NSE; microtubule-associated protein-2a, MAP-2a; synaptophysin) cell markers. Based on these findings, an oligodendroglioma with neuronal differentiation was diagnosed. Such a brain tumour has to date not been reported for African hedgehogs. At necropsy, a severely filled and dilated urinary bladder was observed, which was presumably caused by a central blockade of the micturition centre in the brain. In the case of neurological symptoms in young hedgehogs, a primary brain tumour should, as in adults, be considered as a differential diagnosis. As further differentials, inflammatory-infectious (rabies, herpes, baylisascariosis), degenerative (cardiomyopathy, intervertebral-disc disease), traumatic, alimentary (vitamin-B deficiency) and metabolic-toxic (heat-cold-torpor, hepatic encephalopathy) triggers have to be considered.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligodendroglioma
/
Neoplasias Encefálicas
/
Erizos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
De
Revista:
Tierarztl Prax Ausg K Kleintiere Heimtiere
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2016
Tipo del documento:
Article