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Antihypertensive effect of Korean Red Ginseng by enrichment of ginsenoside Rg3 and arginine-fructose.
Lee, Kyung Hee; Bae, In Young; Park, Song I; Park, Jong-Dae; Lee, Hyeon Gyu.
Afiliación
  • Lee KH; Department of Food and Nutrition, Hanyang University, Seoul, Korea.
  • Bae IY; Department of Food and Fermentation, Far East University, Eumseong, Korea.
  • Park SI; Department of Food and Nutrition, Hanyang University, Seoul, Korea.
  • Park JD; Department of Food and Nutrition, Hanyang University, Seoul, Korea; International Ginseng and Herb Research Institute, Guemsan, Korea.
  • Lee HG; Department of Food and Nutrition, Hanyang University, Seoul, Korea.
J Ginseng Res ; 40(3): 237-44, 2016 Jul.
Article en En | MEDLINE | ID: mdl-27616899
BACKGROUND: Ginsenoside Rg3 and arginine-fructose (Arg-Fru) are known as the hypotensive compounds of Panax ginseng; however, their efficacy on antihypertension has not been reported yet to our best knowledge. Thus, hypotensive components-enriched fraction of red ginseng (HCEF-RG) was prepared from fine root concentrate (FR) and their antihypertensive effects were investigated in spontaneously hypertensive rats (SHR). METHODS: Male SHRs were divided into six groups: control (Wistar Kyoto, SHR); FR 500; FR 1,000; HCEF-RG 500; and HCEF-RG 1,000; samples (mg/kg body weight) were orally administered every day for 8 wk. Blood pressure was monitored at 1 wk, 2 wk, 3 wk, 4 wk, 6 wk, and 8 wk by tail cuff method. At 8 wk after samples administration, mice were killed for the measurement of renin activity (RA), angiotensin-I converting enzyme inhibition, angiotensin II, and nitric oxide (NO) levels in plasma. RESULTS: HCEF-RG with four-fold more Rg3 and 24-fold more Arg-Fru contents was successfully prepared from reacted mixtures of FR and persimmon vinegar (12 times against FR, v/v) at 80°C for 18 h. Both FR 1,000 and HCEF-RG 1,000 showed lowered systolic blood pressure than SHR control group and HCEF-RG 1,000 group exhibited a significant decrease in diastolic blood pressure. RA was significantly lowered in all treated groups, while angiotensin II did not affect by FR and HCEF-RG treatment. However, angiotensin-I converting enzyme inhibition and NO in FR 1,000 and HCEF-RG 1,000 were significantly increased compared with SHR control group. CONCLUSION: HCEF-RG is more effective and useful for alleviating hypertension than FR, implying the health benefit of Rg3 and Arg-Fru.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Ginseng Res Año: 2016 Tipo del documento: Article Pais de publicación: Corea del Sur

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Ginseng Res Año: 2016 Tipo del documento: Article Pais de publicación: Corea del Sur