The lysosome as a command-and-control center for cellular metabolism.
J Cell Biol
; 214(6): 653-64, 2016 09 12.
Article
en En
| MEDLINE
| ID: mdl-27621362
ABSTRACT
Lysosomes are membrane-bound organelles found in every eukaryotic cell. They are widely known as terminal catabolic stations that rid cells of waste products and scavenge metabolic building blocks that sustain essential biosynthetic reactions during starvation. In recent years, this classical view has been dramatically expanded by the discovery of new roles of the lysosome in nutrient sensing, transcriptional regulation, and metabolic homeostasis. These discoveries have elevated the lysosome to a decision-making center involved in the control of cellular growth and survival. Here we review these recently discovered properties of the lysosome, with a focus on how lysosomal signaling pathways respond to external and internal cues and how they ultimately enable metabolic homeostasis and cellular adaptation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Metabolismo Energético
/
Lisosomas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Cell Biol
Año:
2016
Tipo del documento:
Article