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A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease.
Don, Emily K; Formella, Isabel; Badrock, Andrew P; Hall, Thomas E; Morsch, Marco; Hortle, Elinor; Hogan, Alison; Chow, Sharron; Gwee, Serene S L; Stoddart, Jack J; Nicholson, Garth; Chung, Roger; Cole, Nicholas J.
Afiliación
  • Don EK; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Formella I; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Badrock AP; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Hall TE; 2 Institute for Molecular Bioscience, University of Queensland , Brisbane, Australia .
  • Morsch M; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Hortle E; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Hogan A; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Chow S; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Gwee SS; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Stoddart JJ; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Nicholson G; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
  • Chung R; 3 ANZAC Research Institute, Concord Hospital, University of Sydney , Sydney, Australia .
  • Cole NJ; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .
Zebrafish ; 14(1): 69-72, 2017 02.
Article en En | MEDLINE | ID: mdl-27631880
ABSTRACT
Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Animales Modificados Genéticamente / Elementos Transponibles de ADN / Técnicas de Transferencia de Gen / Enfermedades Neurodegenerativas / Enfermedades del Sistema Nervioso Límite: Animals Idioma: En Revista: Zebrafish Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Animales Modificados Genéticamente / Elementos Transponibles de ADN / Técnicas de Transferencia de Gen / Enfermedades Neurodegenerativas / Enfermedades del Sistema Nervioso Límite: Animals Idioma: En Revista: Zebrafish Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Australia