Design, synthesis and biological evaluation of novel benzo-&#945;-pyrone containing piperazine derivatives as potential BRAF<sup>V600E</sup> inhibitors.

Chen, Long-Wang; Wang, Ze-Feng; Zhu, Bo; Man, Ruo-Jun; Liu, Yan-Dong; Zhang, Yuan-Heng; Wang, Bao-Zhong; Wang, Zhong-Chang; Zhu, Hai-Liang

Design, synthesis and biological evaluation of novel benzo-α-pyrone containing piperazine derivatives as potential BRAF^V600E inhibitors.

Chen, Long-Wang; Wang, Ze-Feng; Zhu, Bo; Man, Ruo-Jun; Liu, Yan-Dong; Zhang, Yuan-Heng; Wang, Bao-Zhong; Wang, Zhong-Chang; Zhu, Hai-Liang.

Afiliación

Chen LW; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.
Wang ZF; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.
Zhu B; Jiangsu Chia Tai Tianqing Pharmaceutical Co., Ltd, Nanjing 210000, People's Republic of China.
Man RJ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.
Liu YD; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.
Zhang YH; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.
Wang BZ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.
Wang ZC; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.
Zhu HL; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address: zhuhl@nju.edu.cn.

Bioorg Med Chem Lett ; 26(20): 4983-4991, 2016 10 15.

Article en En | MEDLINE | ID: mdl-27634195

Asunto(s)

Piperazinas/química; Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores; Pironas/química; Pironas/farmacología; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Fragmentación del ADN/efectos de los fármacos; Diseño de Fármacos; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Simulación del Acoplamiento Molecular; Pironas/síntesis química

Palabras clave

BRAF(V600E); Benzo-α-pyrone; Docking simulation; Melanoma; Virtual screening

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Pironas / Proteínas Proto-Oncogénicas B-raf Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido

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