Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics.
Prog Neurobiol
; 151: 237-253, 2017 04.
Article
en En
| MEDLINE
| ID: mdl-27634227
ABSTRACT
Monoamines are key neuromodulators involved in a variety of physiological and pathological brain functions. Classical studies using physiological and pharmacological tools have revealed several essential aspects of monoaminergic involvement in regulating the sleep-wake cycle and influencing sensory responses but many features have remained elusive due to technical limitations. The application of optogenetic tools led to the ability of monitoring and controlling neuronal populations with unprecedented temporal precision and neurochemical specificity. Here, we focus on recent advances in revealing the roles of some monoamines in brain state control and sensory information processing. We summarize the central position of monoamines in integrating sensory processing across sleep-wake states with an emphasis on research conducted using optogenetic techniques. Finally, we discuss the limitations and perspectives of new integrated experimental approaches in understanding the modulatory mechanisms of monoaminergic systems in the mammalian brain.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Monoaminas Biogénicas
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Vías Aferentes
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Optogenética
Límite:
Animals
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Humans
Idioma:
En
Revista:
Prog Neurobiol
Año:
2017
Tipo del documento:
Article