Serum fatty acids in infants, reflecting family fish consumption, were inversely associated with allergy development but not related to farm residence.
Acta Paediatr
; 105(12): 1462-1471, 2016 Dec.
Article
en En
| MEDLINE
| ID: mdl-27637371
ABSTRACT
AIM:
In this study, differences in serum fatty acid patterns between farm and nonfarm infants were investigated and related to subsequent allergy development. We also related allergy-related serum fatty acids to maternal diet and breast milk fatty acids.METHODS:
The FARMFLORA birth cohort included 28 farm and 37 nonfarm infants. Serum was obtained from 21 farm infants and 29 controls at four months post-partum and analysed for phospholipid fatty acids. Allergy was diagnosed by paediatricians at three years of age.RESULTS:
Serum fatty acid patterns were similar in farm and control infants, although farm infants had lower 181 omega-7 proportions. Serum proportions of eicosapentaenoic acid (EPA) were unrelated to farming status, but lower in children who subsequently developed allergy, with an odds ratio of 0.47 and 95% confidence interval of 0.27-0.83 (p = 0.01) for every 0.1% EPA increase. The infants' serum EPA proportions correlated with breast milk EPA proportions, which, in turn, correlated with maternal oily fish intake during lactation.CONCLUSION:
The allergy-protective effect of farming was not linked to infant serum fatty acid composition. However, healthy infants had higher proportions of EPA in their sera, probably reflecting a family diet rich in fish, compared to subsequently allergic children.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenómenos Fisiologicos Nutricionales Maternos
/
Ácidos Grasos
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Granjas
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Hipersensibilidad
/
Leche Humana
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Animals
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Child, preschool
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Female
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Humans
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Infant
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Male
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Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
Acta Paediatr
Año:
2016
Tipo del documento:
Article
País de afiliación:
Suecia