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In vivo proof-of-concept of removal of the huntingtin caspase cleavage motif-encoding exon 12 approach in the YAC128 mouse model of Huntington's disease.
Casaca-Carreira, João; Toonen, Lodewijk J A; Evers, Melvin M; Jahanshahi, Ali; van-Roon-Mom, Willeke M C; Temel, Yasin.
Afiliación
  • Casaca-Carreira J; Departments of Neurosurgery Maastricht University Medical Center, Maastricht, The Netherlands; Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; European Graduate School of Neuroscience (EURON), The Netherlands. Electronic address: j.casacacarreira@maastrichtuniversity
  • Toonen LJA; Department of Human Genetics, Leiden University Medical Center, The Netherlands.
  • Evers MM; Department of Human Genetics, Leiden University Medical Center, The Netherlands; Department of Research & Development, uniQure, Amsterdam, The Netherlands.
  • Jahanshahi A; Departments of Neurosurgery Maastricht University Medical Center, Maastricht, The Netherlands; Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; European Graduate School of Neuroscience (EURON), The Netherlands.
  • van-Roon-Mom WMC; Department of Human Genetics, Leiden University Medical Center, The Netherlands.
  • Temel Y; Departments of Neurosurgery Maastricht University Medical Center, Maastricht, The Netherlands; Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; European Graduate School of Neuroscience (EURON), The Netherlands. Electronic address: y.temel@maastrichtuniversity.nl.
Biomed Pharmacother ; 84: 93-96, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27639545

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Exones / Enfermedad de Huntington / Caspasas / Modelos Animales de Enfermedad / Proteína Huntingtina Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2016 Tipo del documento: Article Pais de publicación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Exones / Enfermedad de Huntington / Caspasas / Modelos Animales de Enfermedad / Proteína Huntingtina Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2016 Tipo del documento: Article Pais de publicación: Francia