Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia.

Kasar, S; Brown, J R

Kasar, S; Brown, J R.

Afiliación

Kasar S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brown JR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Mol Cell Oncol ; 3(4): e1157667, 2016 Jul.

Article en En | MEDLINE | ID: mdl-27652313

ABSTRACT

ABSTRACT

Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes-2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature-that operate at different times throughout CLL evolution.

Palabras clave

CLL; Whole genome sequencing; mutation signature; somatic hypermutation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Cell Oncol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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