Hexanedione effects on protein phosphorylation in rat peripheral nerve.
Brain Res
; 491(2): 366-70, 1989 Jul 10.
Article
en En
| MEDLINE
| ID: mdl-2765891
ABSTRACT
Rats were treated with either 2,5-hexanedione (2,5-HD), 1,6-hexanediol (1,6-HDIOL), or saline for 7, 15 or 24 days. Protein phosphorylation was measured in proximal and distal sciatic nerve segments following incubation with [32P]orthophosphate. In proximal segments, 2,5-HD administration caused selective time-dependent increases in isotope incorporation in a 55 kDa protein, tentatively identified as tubulin, and a 180 kDa protein. Enhanced phosphorylation was highest at 24 days when motor function was most impaired. Administration of 1,6-HDIOL produced no consistent phosphorylation changes. Animals intoxicated with 3,4-dimethyl-2,5-hexanedione for 12 days showed proximal region increases in phosphorylation of the 55 and 180 kDa proteins and the major myelin proteins, Po and Pr.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nervio Ciático
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1989
Tipo del documento:
Article