T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time.

Miyahisa, Ikuo; Suzuki, Hideo; Mizukami, Atsushi; Tanaka, Yukiya; Ono, Midori; Hixon, Mark S; Matsui, Junji

Miyahisa, Ikuo; Suzuki, Hideo; Mizukami, Atsushi; Tanaka, Yukiya; Ono, Midori; Hixon, Mark S; Matsui, Junji.

Afiliación

Miyahisa I; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Suzuki H; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Mizukami A; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Tanaka Y; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Ono M; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.
Hixon MS; Takeda California Inc. , 10410 Science Center Drive, San Diego, California 92121, United States.
Matsui J; Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd. , 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.

ACS Med Chem Lett ; 7(9): 868-72, 2016 Sep 08.

Article en En | MEDLINE | ID: mdl-27660693

Palabras clave

Delta-5 desaturase; T-3364366; mechanism of action (MOA); slow-binding inhibition

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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