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Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide.
Villa, Valentina; Thellung, Stefano; Bajetto, Adriana; Gatta, Elena; Robello, Mauro; Novelli, Federica; Tasso, Bruno; Tonelli, Michele; Florio, Tullio.
Afiliación
  • Villa V; Laboratory of Pharmacology, Department of Internal Medicine, and Center of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genoa, Italy.
  • Thellung S; Laboratory of Pharmacology, Department of Internal Medicine, and Center of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genoa, Italy.
  • Bajetto A; Laboratory of Pharmacology, Department of Internal Medicine, and Center of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genoa, Italy.
  • Gatta E; Department of Physics, University of Genova, Genoa, Italy.
  • Robello M; Department of Physics, University of Genova, Genoa, Italy.
  • Novelli F; Department of Pharmacy, University of Genova, 16132 Genoa, Italy.
  • Tasso B; Department of Pharmacy, University of Genova, 16132 Genoa, Italy.
  • Tonelli M; Department of Pharmacy, University of Genova, 16132 Genoa, Italy.
  • Florio T; Laboratory of Pharmacology, Department of Internal Medicine, and Center of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genoa, Italy. Electronic address: Tullio.florio@unige.it.
Pharmacol Res ; 113(Pt A): 500-514, 2016 11.
Article en En | MEDLINE | ID: mdl-27667770
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dinoprostona / Lipopolisacáridos / Neuroglía / Especies Reactivas de Oxígeno / Celecoxib / Proteínas Priónicas / Inflamación / Óxido Nítrico Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dinoprostona / Lipopolisacáridos / Neuroglía / Especies Reactivas de Oxígeno / Celecoxib / Proteínas Priónicas / Inflamación / Óxido Nítrico Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos