Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease.

Pal, Rinku; Ke, Qingen; Pihan, German A; Yesilaltay, Ayce; Penman, Marsha L; Wang, Li; Chitraju, Chandramohan; Kang, Peter M; Krieger, Monty; Kocher, Olivier

Pal, Rinku; Ke, Qingen; Pihan, German A; Yesilaltay, Ayce; Penman, Marsha L; Wang, Li; Chitraju, Chandramohan; Kang, Peter M; Krieger, Monty; Kocher, Olivier.

Afiliación

Pal R; Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Ke Q; Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Pihan GA; Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Yesilaltay A; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts; and.
Penman ML; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts; and.
Wang L; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts; and.
Chitraju C; Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts.
Kang PM; Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Krieger M; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts; and.
Kocher O; Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; okocher@bidmc.harvard.edu.

Am J Physiol Heart Circ Physiol ; 311(6): H1392-H1408, 2016 12 01.

Article en En | MEDLINE | ID: mdl-27694217

Asunto(s)

Corteza Suprarrenal/metabolismo; Hipercolesterolemia/genética; Células Intersticiales del Testículo/metabolismo; Hígado/metabolismo; Ovario/metabolismo; Receptores Depuradores de Clase B/genética; Anemia Macrocítica/genética; Animales; Apolipoproteínas E/genética; Enfermedad de la Arteria Coronaria/genética; Enfermedad de la Arteria Coronaria/mortalidad; Enfermedad Coronaria/genética; Enfermedad Coronaria/mortalidad; Oclusión Coronaria/genética; Oclusión Coronaria/mortalidad; Femenino; Técnicas de Sustitución del Gen; Hematopoyesis Extramedular/genética; Immunoblotting; Lipoproteínas HDL/genética; Masculino; Ratones; Mutación; Reacción en Cadena de la Polimerasa; Receptores de Lipoproteína/genética; Reticulocitosis/genética; Esplenomegalia/genética; Trombocitopenia/genética; Transcriptoma

Palabras clave

PDZ domains; SR-BI; atherosclerosis; myocardial infarction; steroidogenic organs

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ovario / Corteza Suprarrenal / Receptores Depuradores de Clase B / Hipercolesterolemia / Células Intersticiales del Testículo / Hígado Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Am J Physiol Heart Circ Physiol Asunto de la revista: CARDIOLOGIA / FISIOLOGIA Año: 2016 Tipo del documento: Article

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