Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy.
Kidney Int
; 35(6): 1400-4, 1989 Jun.
Article
en En
| MEDLINE
| ID: mdl-2770118
ABSTRACT
In bone marrow cultures of 15 patients with primary IgA nephropathy we found significantly (P = 0.02) increased synthesis of both monomeric and polymeric IgA1 compared to 23 controls, by using high performance liquid chromatography (HPLC) fractionation of culture supernatants. The relative contribution of polymeric to total IgA1 produced was not different for the two groups. Two-color immunofluorescence studies of the percentage of bone marrow IgA1 plasma cells able to bind secretory component in vitro showed no difference between patients and controls. In the sera of patients with primary IgA nephropathy the relative contribution of IgA1 polymers to total IgA1 was also similar to controls. These results indicate that in IgA nephropathy, the increased IgA production in the bone marrow is restricted to the IgA1 subclass. The production of both monomeric and polymeric IgA1 is increased in patients during a quiescent phase of the disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Ósea
/
Inmunoglobulina A
/
Glomerulonefritis por IGA
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Kidney Int
Año:
1989
Tipo del documento:
Article
País de afiliación:
Países Bajos