Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea.
J Nat Prod
; 79(10): 2590-2598, 2016 10 28.
Article
en En
| MEDLINE
| ID: mdl-27704807
ABSTRACT
Fourteen new rearranged 6/6/5/6-fused triterpenoid acids, namely, kadcoccine acids A-N (1-14), were isolated from an EtOAc-soluble extract of the stems of Kadsura coccinea. Their structures were characterized mainly by analyzing 1D and 2D NMR and HRESIMS data and were shown to feature a rare 14(13â12)-abeo-lanostane skeleton. Compounds 7 and 8 represented the first examples of a 5-substituted 2(5H)-furanone motif on the C-17 side chain of this skeleton. The absolute configurations of C-23 for compounds 1, 7, and 8 were determined by comparison of their experimental electronic circular dichroism spectra. All the isolates were screened for their in vitro cytotoxicity against six human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW-480, and HeLa), and compounds 2 and 8 exhibited weak inhibitory effects with IC50 values ranging from 3.11 to 7.77 µM.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Medicamentos Herbarios Chinos
/
Tallos de la Planta
/
Kadsura
/
Antineoplásicos Fitogénicos
Límite:
Female
/
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2016
Tipo del documento:
Article