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Inhibition of Apoptosis is a Potential Way to Improving Ischemic Brain Tolerance in Combined Exposure to Hypercapnia and Hypoxia.
Tregub, P P; Malinovskaya, N A; Kulikov, V P; Salmina, A B; Nagibaeva, M E; Zabrodina, A S; Gertsog, G E; Antonova, S K.
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  • Tregub PP; Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia. pfiza_asmu@mail.ru.
  • Malinovskaya NA; Reserach Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. pfiza_asmu@mail.ru.
  • Kulikov VP; V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
  • Salmina AB; Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
  • Nagibaeva ME; Reserach Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
  • Zabrodina AS; V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of the Russian Federation, Krasnoyarsk, Russia.
  • Gertsog GE; Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
  • Antonova SK; Altai State Medical University, Ministry of Health of the Russian Federation, Barnaul, Russia.
Bull Exp Biol Med ; 161(5): 666-669, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27709386
We compared the intensity of apoptosis in the peri-infarction area of the brain after isolated and combined exposure to hypoxia and hypercapnia prior to focal ischemic stroke modeling. Hypoxia and hypercapnia reduced the number of TUNEL-positive cells in the peri-infarction area, and their combination was most effective in comparison with effects of isolated exposures. The maximum neuroprotective effect of combined exposure to hypoxia and hypercapnia in comparison with isolated exposures was determined by inhibition of apoptosis in the peri-infarction zone.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipoxia Encefálica / Isquemia Encefálica / Apoptosis / Hipercapnia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2016 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipoxia Encefálica / Isquemia Encefálica / Apoptosis / Hipercapnia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2016 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos