Novel tubulin-targeted cell penetrating antimitotic octapeptide.
Chem Commun (Camb)
; 52(85): 12657-12660, 2016 Oct 18.
Article
en En
| MEDLINE
| ID: mdl-27713939
ABSTRACT
An antimitotic cell penetrating octapeptide containing single Arg amino acid is discovered, which strongly binds with the exchangeable GTP/GDP binding site of tubulin, inhibits tubulin polymerization, reduces kinesin driven microtubule motility, activates apoptotic and mitotic check point proteins, induces apoptotic death and significantly inhibits the multicellular tumor spheroid growth of HeLa cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tubulina (Proteína)
/
Apoptosis
/
Antimitóticos
/
Péptidos de Penetración Celular
/
Mitosis
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
India