Risk factors for ocular surface squamous neoplasia in Kenya: a case-control study.
Trop Med Int Health
; 21(12): 1522-1530, 2016 12.
Article
en En
| MEDLINE
| ID: mdl-27714903
ABSTRACT
OBJECTIVE:
To determine modifiable risk factors of ocular surface squamous neoplasia (OSSN) in Kenya using disease-free controls.METHODS:
Adults with conjunctival lesions were recruited at four eye care centres in Kenya and underwent excision biopsy. An equal number of controls having surgery for conditions not affecting the conjunctiva and unrelated to ultraviolet light were group-matched to cases by age group, sex and eye care centre. Associations of risk factors with OSSN were evaluated using multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Continuous variables were compared using the t-test or the Wilcoxon-Mann-Whitney U-test depending on their distribution.RESULTS:
A total of 131 cases and 131 controls were recruited. About two-thirds of participants were female, and the mean age of cases and controls was 42.1 years and 43.3 years, respectively. Risk factors for OSSN were HIV infection without antiretroviral therapy (ART) use (OR = 48.42; 95% CI 7.73-303.31) and with ART use (OR = 19.16; 95% CI 6.60-55.57), longer duration of exposure to the sun in the main occupation (6.9 h/day vs. 4.6 h/day, OR = 1.24; 95% CI 1.10-1.40) and a history of allergic conjunctivitis (OR = 74.61; 95% CI 8.08-688.91). Wearing hats was protective (OR = 0.22; 95% CI 0.07-0.63).CONCLUSION:
Measures to prevent and control HIV, reduce sun exposure such as wearing hats and control allergic conjunctivitis are recommended.Palabras clave
HIV; VIH; allergic conjunctivitis; antiretroviral therapy; conjonctivite allergique; conjuntivitis alérgica; facteurs de risque; factores de riesgo; neoplasia escamosa de la superficie ocular; néoplasie squameuse de la surface oculaire; ocular surface squamous neoplasia; radiación ultravioleta; rayonnement ultraviolet; risk factors; terapia antiretroviral; traitement antirétroviral; ultraviolet radiation
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Luz Solar
/
Conjuntivitis Alérgica
/
Carcinoma de Células Escamosas
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Infecciones por VIH
/
Conjuntiva
/
Neoplasias de la Conjuntiva
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Africa
Idioma:
En
Revista:
Trop Med Int Health
Asunto de la revista:
MEDICINA TROPICAL
/
SAUDE PUBLICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido