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The Effect of l-Arginine on Dural Healing After Experimentally Induced Dural Defect in a Rat Model.
Ahmadi, Sayed Ali; Jafari, Mostafa; Darabi, Mohammad Reza; Chehrei, Ali; Rezaei, Masoud; Mirsalehi, Marjan.
Afiliación
  • Ahmadi SA; Department of Neurosurgery, Arak University of Medical Sciences, Arak, Iran.
  • Jafari M; Student Research Committee, Arak University of Medical Sciences, Arak, Iran. Electronic address: Mostafa.medicine87@gmail.com.
  • Darabi MR; Department of Anatomy, Arak University of Medical Sciences, Arak, Iran.
  • Chehrei A; Thyroid Research Center, Arak University of Medical Sciences, Arak, Iran.
  • Rezaei M; Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Mirsalehi M; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
World Neurosurg ; 97: 98-103, 2017 Jan.
Article en En | MEDLINE | ID: mdl-27717775
ABSTRACT

BACKGROUND:

Incomplete repair of the dura mater may result in numerous complications such as cerebrospinal fluid leakage and meningitis. For this reason, accurate repair of the dura mater is essential. In this study, the effect of systemic and local supplementation of l-arginine on dural healing was evaluated.

METHODS:

Thirty male Wistar rats were used and divided into control, local, and systemic l-arginine groups, with 10 rats in each. In each group, a 5-mm experimental incision was made at the lumbar segment of the dura mater and cerebrospinal fluid leakage was induced. Each group was divided into 2 subgroups and at the end of the first and sixth weeks, the rats were killed and the damaged segments of the dura were separated, histologically evaluated and the dural healing indicators including cell types, granulation tissue formation, collagen deposit, and vascularization were compared between groups.

RESULTS:

The systematic supplementation of l-arginine showed a significant effect in dural healing compared with the control group. After the first week, granulation formation increased considerably (P < 0.031), and after 6 weeks, collagen deposition and neovascularization were significantly different compared with the control group (P < 0.030; P < 0.009). In comparison between different groups at the end of the first and sixth weeks, maximum changes in healing indicators were observed in the systemic group and the least variations were related to the control group.

CONCLUSIONS:

The systemic supplementation of l-arginine may accelerate dural healing by increasing the level of granulation tissue formation, collagen deposition, and vascularization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arginina / Cicatrización de Heridas / Pérdida de Líquido Cefalorraquídeo Límite: Animals Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2017 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arginina / Cicatrización de Heridas / Pérdida de Líquido Cefalorraquídeo Límite: Animals Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2017 Tipo del documento: Article País de afiliación: Irán